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Gene expression profiling in ALS: past, present and future
Published on Jul 21, 2017864 Views
Gene expression profiling has come a long way since the term was first widely used in the mid to late 1990’s. With the advent of microarrays allowing the expression levels of increasing numbers of
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Chapter list
Gene Expression Profiling in ALS: Past, Present & Future00:00
Overview - 100:21
Introduction01:04
Uses in ALS02:25
Past: GEP in ALS - 102:55
Past: GEP in ALS - 204:05
SOD1-ALS & NRF204:30
ALS & NRF2 - 105:45
ALS & NRF2 - 206:13
ALS & NRF2 - 306:37
ALS & PTEN/PI3K - 107:08
ALS & PTEN/PI3K - 207:58
(G4C2)n Cell Model - 108:13
(G4C2)n Cell Model - 208:49
(G4C2)n Cell Model - 308:59
PTEN/PI3K/AKT09:51
PTEN Knockdown Rescues Toxicity10:17
RNA Splicing - 110:44
RNA Splicing - 212:04
RNA Splicing - 312:16
Past: Disease Mechanisms13:08
Uses in ALS13:21
Monitoring Progression - 113:26
Monitoring Progression - 214:23
ALS Biomarkers14:44
Overview - 215:03
Present: miRNA Biomarkers15:09
miRNA Biomarkers - 115:36
miRNA Biomarkers - 216:40
miRNA Biomarkers - 317:41
miRNA Biomarkers - 418:32
Profiling Cellular Compartments - 119:03
Cyto v Nuclear - 119:31
Cyto v Nuclear - 219:55
Cyto v Nuclear - 320:11
Missense v Truncation20:42
Present: RNA-Seq21:09
Missense/Truncation21:59
Profiling Cellular Compartments - 222:56
Profiling Cellular Compartments - 323:28
Overview - 323:55
Future: Clinical Care - 124:02
Future: Clinical Care - 224:39
Future...26:00
Future GEP?26:26
Acknowledgements26:43
Any Questions?26:57