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Two G-quadruplex structures adopted by oligonucleotide model of ALS and FTD linked GGGGCC repeats
Published on Jul 21, 2017820 Views
The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a large increase in the number of GGGGCC repeats located within the non-coding region of
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Two G-quadruplex structures adopted by oligonucleotide model of ALS and FTD linked GGGGCC repeats00:00
Nucleotide repeat expansion in human diseases00:13
Nucleotide repeat expansion in human diseases: ALS and FTD00:48
G-quadruplexes: unusual four-stranded structures formed by guanine rich nucleic acids in the presence of K+ or Na+ ions01:08
Potential G-quadruplex forming sequences are enriched in some critical parts of the human genome02:04
Hypothesis: unusual secondary structures adopted by GGGGCC repeat contribute to repeat instability02:40
Hypothesis: unusual structures adopted by GGGGCC repeats initiate a pathogenic chain of events03:28
Nuclear magnetic resonance (NMR): detection of G-quadruplex formation04:39
Nuclear magnetic resonance (NMR): structure determination05:46
Oligonucleotide model of GGGGCC repeat folds into two major G-quadruplex structures06:23
Two folding condition determine relative populations of AQU and NAN07:05
AQU and NAN share a similar antiparallel fold but exhibit distinct structural features - 108:18
AQU and NAN share a similar antiparallel fold but exhibit distinct structural features - 208:55
Acknowledgement10:32