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Two G-quadruplex structures adopted by oligonucleotide model of ALS and FTD linked GGGGCC repeats
Published on 2017-07-21824 Views
The most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is a large increase in the number of GGGGCC repeats located within the non-coding region of
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Presentation
Two G-quadruplex structures adopted by oligonucleotide model of ALS and FTD linked GGGGCC repeats00:00
Nucleotide repeat expansion in human diseases00:13
Nucleotide repeat expansion in human diseases: ALS and FTD00:48
G-quadruplexes: unusual four-stranded structures formed by guanine rich nucleic acids in the presence of K+ or Na+ ions01:08
Potential G-quadruplex forming sequences are enriched in some critical parts of the human genome02:04
Hypothesis: unusual secondary structures adopted by GGGGCC repeat contribute to repeat instability02:40
Hypothesis: unusual structures adopted by GGGGCC repeats initiate a pathogenic chain of events03:28
Nuclear magnetic resonance (NMR): detection of G-quadruplex formation04:39
Nuclear magnetic resonance (NMR): structure determination05:46
Oligonucleotide model of GGGGCC repeat folds into two major G-quadruplex structures06:23
Two folding condition determine relative populations of AQU and NAN07:05
AQU and NAN share a similar antiparallel fold but exhibit distinct structural features - 108:18
AQU and NAN share a similar antiparallel fold but exhibit distinct structural features - 208:55
Acknowledgement10:32