Thematic International Conference on Bio-, Nano- and Space Technologies, E U & Science Centers Collaboration

Structural Properties of Antimicrobial Peptides acting on Bacterial

author: Boštjan Japelj, Drug Discovery Department, LEK

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*Slides*
0:00	STRUCTURAL PROPERTIES OF ANTIMICROBIAL PEPTIDES ACTING ON BACTERIAL MEMBRANES
0:29	Antibiotics – “miracle drugs”
1:08	Cationic antimicrobial peptides
1:57	- act on membranes and intracellular targets,
2:54	LACTOFERRIN
5:08	NMR study of LF11 + S-LPS, LF11 + SDS, LF11 + DPC
6:52	LF11 + S-LPS
7:36	Comparison of LPS interaction motifs in FhuA (left)1, LF11 (center)2 and polymyxin B (right)3,4
8:32	Comparison of structures LF11+S-LPS, LF11+SDS, LF11+DPC
9:25	N-terminal part of LF11 is protected from fluoresscence quenching
10:35	C12LF11
12:18	P3-55
12:39	P3-55
13:11	Circular dichroism spectra
13:43	Structure of P3-55 in DPC and Structure of P3-55 in SDS
14:57	Positioning and orientation of P3-55 in micelles
15:57	reference and 5 - DSA
16:29	Normalized I/Iref ratios of HN-Ha cross peaks in NOESY spectrum
17:25	Molecular dynamics of P3-55 in DPC
18:46	Mechanism of interaction of ANEPID peptides with the membrane of Gram-negative bacteria.
20:46	Acknowledgements

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