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Modifications of FUS and implications in ALS and FTD
Published on Oct 01, 20151738 Views
Frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) are neurodegenerative disorders with clinical, genetic, and neuropathological overlap. Aberrant cytoplasmic aggregation
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Modifications of FUS and implications in ALS and FTD00:00
Fused in sarcoma00:28
Rules of PY type NLS03:07
Mutations in FUS03:37
Mutations impair nuclear transport04:05
Cytoplasmic aggregates of FUS04:47
Pathological aggregates in neurons06:08
Fus07:31
Effect of Y526 mutations on FUS localization08:01
Effect of Y526 mutations on interaction with TNPO108:43
Tyrosine, Phosphotyrosine, Phenylalanine, Glutamate09:24
C-terminal tyrosine in FUS is phosphorylated09:56
Negative charge Enlargement11:29
Effect of Y526 phosphorylation on interaction with Transportin - 111:46
Effect of Y526 phosphorylation on interaction with Transportin - 212:40
Y526 is important for interaction with TNPO113:52
Cytoplasm, Nucleus14:52
Thank you for your attention15:50