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Psychedelic drugs in science and medicine
Published on Sep 07, 20151559 Views
Psychedelic drugs have been used for millennia by certain cultures and are now being used by scientists and doctors in contemporary science and medicine to understand the brain and treat certain menta
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Chapter list
Psychedelics in science and medicine00:00
What are psychedelics?00:20
How do they work?01:32
Why are psychedelics interesting?04:42
5-HT2AR-mediated effects in animals10:41
How do psychedelics affect the human brain?12:02
LSD fMRI and Meg study12:50
Psychological effects14:34
Two important features of the brain15:25
What’s resting-state functional connectivity?16:51
Network disintegration on LSD18:07
Network desegregation on LSD20:35
Network desegregation with psilocybin (left) But not MDMA (right)21:59
Psychedelic’s action: Key principles23:37
The regressive brain24:20
Infant v psychedelic consciousness24:57
Ego-dissolution → transformative experiences ↑26:59
DMN disintegration ↑ ego disintegration ↑27:55
PH-PCC disconnection ↑ ego disintegration & altered meaning ↑28:55
PH-PCC disconnection ↑ psychosis ↑?30:57
Serotonin 2A receptor stim ↓ mood ↓34:02
Psilocybin for depression37:02
Molecular action, societal change?40:50
A thought43:54
1966: Senator Bobby Kennedy defends LSD research44:32
Thank you46:15