The vulnerability of the structural connectome to stroke in older adults

author: Rok Berlot, Department of Neurology, University Medical Centre Ljubljana
published: Oct. 1, 2015,   recorded: May 2015,   views: 1480
Categories

Slides

Related Open Educational Resources

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Bibliography

Description

Strategic infarction describes how lesions in particular locations have disproportionate effects on brain function. Strategic locations can reflect “bottlenecks” in functional networks for movement or cognition. Another hypothesis is that strategic effects are an emergent property of the brain’s network architecture. We aimed to examine the effect of simulated lesions on the global properties of the structural connectome. Simulated lesions were made in two sets of locations: i) subcortical nuclei recognised as sites of strategic infarction; ii) highly connected hubs that are part of the brain’s “rich club”, a group of highly interconnected hubs that mediate long-distance connectivity in the brain. 39 healthy volunteers aged 53-93 years underwent diffusion-weighted MRI. Whole-brain tractograms were represented as network graphs. Lesions were simulated by removing a node and its connections from the graph. The proportional change in network global efficiency due to each lesion was calculated. Lesions of rich-club nodes led to larger reductions in global efficiency than lesions outside the rich club. Lesions of the precunei produced the largest effect. Among subcortical nodes, vulnerability was highest for thalamic lesions. Age was positively correlated with vulnerability to lesions in the thalami. The structural connectome of healthy individuals aged over 50 is vulnerable to strategic lesions of rich-club nodes, though some of the key hubs are in sites rarely affected by stroke. The vulnerability of the structural connectome to thalamic stroke increases with age. This is likely to be a factor in the influence of age on stroke outcome.

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: