Automated detection of electrocardiographic diagnostic features through an interplay between Spatial Aggregation and Computational Geometry
author: Stefania Tentoni, Istituto di Matematica Applicata e Tecnologie Informatiche, IMATI
Description
Within the medical domain, Functional Imaging provides
methods for effectual visualization of diagnostically relevant
numeric fields, i.e. of spatially referenced measurements of
variables related to organ functions. Unveiling the salient
physical events that underly a functional image is most appropriately
addressed by feature extraction methods that exploit
the domain-specific knowledge combined with spatial
relations at multiple abstraction levels and scales. The identification
of specific patterns that are known to characterize
classes of pathologies provides an important support to the
diagnosis of disturbances, and the assessment of organ functions.
In this work we focus on Electrocardiographic diagnosis
based on epicardial activation fields. This kind of data,
which can now be obtained non invasively from body surface
data through mathematical model-based reconstruction methods,
can hit electrical conduction pathologies that routine surface
ECGs may miss. However, their analysis/interpretation
still requires highly specialized skills that belong to few experts.
Given an epicardial activation field, the automated detection
of salient patterns in it, grounded on the existing interpretation
rationale, would represent a major contribution
towards the clinical use of such valuable tools whose diagnostic
potential is still largely unexplored. We focus on epicardial
activation isochronal maps, which convey information
about the heart electric function in terms of the depolarization
wavefront kinematics. An approach grounded on the integration
of a Spatial Aggregation (SA) method with concepts
borrowed from Computational Geometry provides a computational
framework to extract, from the given activation data,
a few basic features that characterize the wavefront propagation,
as well as a more specific set of diagnostic features
that identify an important class of heart rhythm pathologies,
namely reentry arrhythmias due to block of conduction.
Keywords: Biomedical imaging; functional imaging; image
based diagnosis; spatial aggregation; computational geometry;
electrocardiography; cardiac electrical function.
| Slides | |
| 0:00 | Automated detection of electrocardiographic diagnostic features through an interplay between Spatial Aggregation and Computational Geometry |
| 0:28 | Outline |
| 0:38 | Functional Imaging & Image Based Diagnosis (1) |
| 1:22 | Functional Imaging & Image Based Diagnosis (2) |
| 1:46 | Functional Imaging & Image Based Diagnosis (3) |
| 2:18 | Core task is Feature Extraction |
| 2:22 | Imaging of the cardiac electric activity |
| 4:42 | An example: activation isochrones during VT |
| 5:39 | Excitation starts here (breakthrough site) |
| 5:48 | Spatially dense isochrones ↓ very-slow conduction |
| 6:24 | Conduction block |
| 6:47 | Conduction block Reentry propagation pattern |
| 7:08 | Feature extraction problem |
| 8:36 | Approach & Methods |
| 9:34 | Spatial Aggregation |
| 9:51 | Overview of the abstraction processes |
| 11:00 | Double reentry circuit identification |
| 12:50 | Algorithm (Gross skeleton) (1) |
| 13:39 | Algorithm (Gross skeleton) (2) |
| 14:44 | Algorithm (Gross skeleton) (3) |
| 15:41 | Algorithm (Gross skeleton) (4) |
| 15:58 | Choice of β * (1) |
| 18:15 | Choice of β * (2), (n = 30 perturbations, SNR = 148.3) |
| 19:34 | Choice of β * (3) |
| 19:36 | Choice of β * (4) |
| 21:51 | Some results |
| 22:24 | Check for conduction blocks |
| 23:06 | Classification of propagation lines |
| 24:32 | Conclusions & future work |
| 27:15 | - Questions |
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