Bayesian Inference of transcription factor activity - an application to the fission yeast cell cycle

author: Simon Rogers, University of Glasgow
published: Sept. 7, 2007,   recorded: September 2007,   views: 3716


Related Open Educational Resources

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.


When modeling genetic regulatory interactions, it is often assumed that the mRNA expression of a transcription factor is a reliable proxy for the regulatory activity of that transcription factor. There are many examples where this assumption does not hold due to post-transcriptional and translational modifications of the transcription factor protein. As true transcription factor activity is very difficult to measure, methods to infer it are becoming increasingly common and it is likely that will become increasingly important when building models of regulatory interactions. Previously, we have shown how Bayesian techniques, particularly Markov- Chain Monte-Carlo based sampling, can enable us to make inferences regarding the activity of transcription factors based on the transcript levels of their targets. However, in that work, we only looked at simple regulatory interactions where one transcription factor acted individually on a set of target genes. In this work, we investigate extending this model to the more general (and common) case of multiple transcription factors working together. As an example application, we use data from a small regulatory network from the fission yeast cell cycle in which several transcription factors are known to work together to produce the desired response, and for which plentiful experimental data are available.

See Also:

Download slides icon Download slides: pmnp07_rogers_biot_01.pdf (278.4 KB)

Help icon Streaming Video Help

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Reviews and comments:

Comment1 Camila Sodi, March 24, 2012 at 6:10 p.m.:

Link Building Services Proposal

I am a professional link builder with a team of 20 link builder working under me, we have huge tie ups with USA and UK based web design firm and we provide 10000+ one way links per month.

I have a good solid on-going client base who welcomes you to contact for reference with 110% positive feedback.

Please let me know if I can be any assistance to you in any of your existing/future projects.

One Way Link Building Package (Mix PR from PR1 to PR4)

PR 1 = $ 1
PR 2 = $ 2
PR 3 = $ 3
PR 4 = $ 4

Packages --

50 links = $100
100 links = $200
150 links = $300
200 links = $400

So give us a chance to build our long term business relationship, I am looking forward for your positive response ….

Thanks & Regards
Camila Sodi

P.S. This is an advertisement and a promotional mail strictly on the guidelines of CAN-SPAM act of 2003. We have clearly mentioned the source mail-id of this mail, also clearly mentioned the subject lines and they are in no way misleading in any form. We have found your mail address through our own efforts on the web search and not through any illegal way. If you find this mail unsolicited, please reply with "Remove" in the subject line and we will take care that you do not receive any further promotional mail.

Write your own review or comment:

make sure you have javascript enabled or clear this field: