Reconstructing hidden protein activity by nonparameteric methods

author: Lorenz Wernisch, Birkbeck College, University of London
published: Nov. 6, 2007,   recorded: September 2007,   views: 3076


Related Open Educational Resources

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.


Most of the cellular processes are not accessible to direct measurements. For example, the level of protein activities can often only be assessed indirectly by their effects on gene expression or the modification of other proteins. The exact form of the functional relationships describing such interactions are unknown as well. Nevertheless, some progress can be made by combining factor analysis or dynamical models with nonparametric regression methods, which don't impose any form on reconstructed functions. On the other hand, identifiability becomes are major problem and needs to be balanced against flexibility. I will report on our experience with simulated and experimental data in exploring the limits of reconstructing hidden protein activities and interaction networks.

See Also:

Download slides icon Download slides: pim07_wernisch_rhp_01.pdf (895.1┬áKB)

Help icon Streaming Video Help

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: