Towards a Polymer Model of Genetic Recombination

author: Christopher Penfold, Warwick Systems Biology Centre, University of Warwick
published: Nov. 6, 2007,   recorded: September 2007,   views: 354
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Description

Homologous recombination (HR) refers to the shuffling of genetic material during cellular division e.g., meiosis and mitosis, and in response to environmentally-induced genetic damage. HR occurs preferentially over certain regions, and is notably influenced by physical compartmentalization due to chromosome packing. Although a number of experimental techniques exist for identifying such effect they are generally costly and time-consuming. Here we suggest a Bayesian approach to recom- bination with a mechanistic prior such that we may infer posterior distributions for recombination frequencies and efficiencies between regions where experimental data may be absent.

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