Parameter estimation of ODE's using Support Vector Regression and Qualitative Constraints

author: Paola Bouchet, Université Evry Val d'Essonne
published: Nov. 6, 2007,   recorded: September 2007,   views: 5786


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Dynamical systems used for the modeling of biological networks (such as gene regulatory networks or metabolic networks) are generally based on Ordinary Differential Equations (ODE`s). Although nonlinear ODE`s are commonly used in Systems Biology, their identification and estimation from real data remain a difficult task because of the high number of parameters to estimate compared with the relatively few number of observations.

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