Vrednotenje strukturne primerljivosti podobnih bioloških zdravil z jedrsko magnetno resonanco: od malih proteinov do monoklonskih protiteles

author: Uroš Urleb, Novartis
published: Dec. 8, 2017,   recorded: October 2017,   views: 543
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Description

Jedrska magnetna resonanca (NMR) je metoda, ki jo uporabljamo za določitev strukture proteinov na molekularnem nivoju. Princip delovanja metode je enak magnetni resonanci, ki se uporablja za diagnostične namene v medicini. Z omenjeno metodo so raziskovalci primerjali strukturi dveh biološko podobnih molekul, ki so jih razvili v podjetju Lek (član skupine Novartis), z referenčnima originatorskima molekulama in dokazali, da sta si podobni. To je omogočilo registracijo in trženje biološko podobnih zdravil.

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