Statistical Inference of Protein Structure and Function
published: Jan. 12, 2011, recorded: December 2010, views: 1340
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The study of the structure and function of proteins serves up many problems that offer challenges and opportunities for computational and statistical research. I will overview my experiences in several such problem domains, ranging from domains where off-the-shelf ideas can be fruitfully applied to domains that require new thinking. These are:
- the identification of active sites in enzymes;
- the modeling of protein backbone configurations;
- the prediction of molecular function based on phylogeny;
- alignment and phylogenetic inference.
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