On the stability and interpretability of prognosis signatures in breast cancer

author: Anne-Claire Haury, Institut Curie
published: Nov. 8, 2010,   recorded: October 2010,   views: 8399


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In this work we wish to answer the questions: (1) how much can we trust the list of genes and the biological functions found in a predictive signature and (2) how do common feature selection methods compare to each other in this regard? We propose a rigorous framework to assess the accuracy, the stability and the interpretability of a feature selection method and compare 8 common feature selection methods as well as ensemble feature selection variants on three breast cancer datasets. Results highlight the very low robustness of most existing methods, including ensemble methods, and raise a warning about the over interpretation of published signatures in terms of genes and biological processes.

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Comment1 Mark, November 28, 2010 at 5:51 p.m.:

All cancers can be cured by proper eating. Eating lots of organic green vegetables, staying away from meat and starches (sugars), positive thinking, and exercise.

This is the simple fact that the medical industry does not want you to know. The medical industry is a HUGE business and they must keep creating ways to take your money.

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