Gene-based bin analysis of genome-wide association studies

author: Nicolas Omont, Serono, biotech and beyond

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*Slides*
0:00	Bin analysis of genome-wide association study
0:34	Bin analysis of genome-wide study - 1
0:58	Transmission and recombination
2:09	Haplotype blocks (HB)
3:09	Data – association study
3:11	Genetic disease - 1
4:12	Genetic disease - 2
4:54	Association study: example - 1
6:36	Association study: cost problem
7:03	Single nucleotide polymorphism
8:25	Association study: example - 2
9:06	Association study: example - 3
10:56	The Serono association study
12:20	Analysis
12:35	Method
12:44	The ideal vision
14:17	FDR estimation (no control)
17:03	Multiple testing problem - 1
17:54	Multiple testing problem - 2
19:05	Bin definition - 1
20:26	Bin definition - 2
21:02	Bin definition: loss of power example - 1
21:29	Bin definition: loss of power example - 2
21:30	Statistical test:
22:17	Estimation
23:02	Results
23:02	Results: bins
24:03	P-value distribution
25:17	FDR: FDR vs p-value
25:46	Number of bins selected
26:23	FDR overestimation
27:09	Conclusion - 1
28:05	Conclusion - 2
28:42	- Questions
29:41	- Questions

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