Identification of functional modules based on transcriptional regulation structure
author:
Etienne Birmelé,
Universite’ d’Evry
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| Slides | |
| 0:00 | Identification of functional modules based on transcriptional regulation structure |
| 1:01 | Introduction |
| 3:02 | Outline |
| 3:11 | Learning the regulation structure |
| 3:14 | General overview |
| 4:18 | Regulation model |
| 7:20 | Licorn Step 1: Frequent co-regulator sets |
| 8:03 | General overview |
| 8:37 | Licorn Step 1: Frequent co-regulator sets |
| 10:21 | Regulation model |
| 10:44 | Licorn Step 2: best putative GRN’s |
| 11:23 | Regulation model |
| 11:39 | Licorn Step 3 - Statistical significance |
| 12:16 | Summary of the regulation structure learning step |
| 12:55 | Clustering |
| 13:07 | The three steps to detect modules |
| 13:49 | The similarity measure |
| 16:03 | The clustering algorithm |
| 16:55 | The similarity measure |
| 17:19 | The score of a clustering - 1 |
| 18:17 | The score of a clustering - 2 |
| 18:46 | Summary of the clustering step |
| 19:10 | Application to Yeast |
| 19:12 | The data set |
| 20:01 | Mapping to GO terms - 1 |
| 20:32 | Mapping to GO terms - 2 |
| 21:33 | Perspectives |
| 22:54 | - Questions |
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