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Machine Learning in Systems Biology
Pascal

Identification of functional modules based on transcriptional regulation structure

author: Etienne Birmelé, Universite’ d’Evry
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Slides
0:00 Identification of functional modules based on transcriptional regulation structure
1:01 Introduction
3:02 Outline
3:11 Learning the regulation structure
3:14 General overview
4:18 Regulation model
7:20 Licorn Step 1: Frequent co-regulator sets
8:03 General overview
8:37 Licorn Step 1: Frequent co-regulator sets
10:21 Regulation model
10:44 Licorn Step 2: best putative GRN’s
11:23 Regulation model
11:39 Licorn Step 3 - Statistical significance
12:16 Summary of the regulation structure learning step
12:55 Clustering
13:07 The three steps to detect modules
13:49 The similarity measure
16:03 The clustering algorithm
16:55 The similarity measure
17:19 The score of a clustering - 1
18:17 The score of a clustering - 2
18:46 Summary of the clustering step
19:10 Application to Yeast
19:12 The data set
20:01 Mapping to GO terms - 1
20:32 Mapping to GO terms - 2
21:33 Perspectives
22:54 - Questions

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