Neurobiology of Memory: How Do We Acquire, Consolidate and Recall Memory

author: Susumu Tonegawa, Department of Biology, Massachusetts Institute of Technology, MIT
published: Sept. 8, 2010,   recorded: June 2003,   views: 9155

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In labs around the world, mice learn to navigate complex mazes, locate chocolaty rewards, and after an interval, run the mazes again with maximum efficiency, swiftly collecting all the sweets. But in Susumu Tonegawa’s lab, the mutant mice he has created cannot perform these tasks. Tonegawa “ knocks out” a gene that impairs a specific part of the mouse hippocampus, the area of the brain responsible for spatial memory, among other things. Mutant mice struggle to acquire and recall information about their surroundings. Tonegawa’s work involves manipulating genes to explore memory and learning from the most basic biochemical and cellular levels, up to the most complex behaviors. One of Tonegawa’s goals in designing defective mice is to simulate profound human disorders, like schizophrenia.

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Reviews and comments:

Comment1 Andrew Wolstenholme, February 23, 2015 at 3:47 a.m.:

Mr. Tonegawa has an incredible ability to express complex ideas in his second language.
May I point out that he frequently refers to "cartoons" when he means "slides".
This slide show the hippocampus...etc
A cartoon is a a picture or movie which has the element of humour.

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