Statistical learning of biological networks: a brief overview
Description
Identification of biological networks such as signalling pathways, gene regulatory networks, protein-protein interaction networks and metabolic networks is considered as a key challenge in computational biology. Using machine learning framework, this problem can be addressed using different points of view, depending of course on the nature of the biological interactions to be inferred but also on the level of abstraction of the chosen modeling and the amount of prior knowledge available. Since 2000, research in statistical learning of biological networks have given rise to a rich panel of approaches whose interest overcomes the field of computational biology. Network identification has been tackled using large scale data-mining approaches, supervised predictive approaches and reverse-modeling approaches. In this sole last family, it is very instructive to focus on the numerous graphical models that have been proposed so far such as Graphical Gaussian Models, Bayesian networks, Dynamical Bayesian networks and state-space models. I will present a short review of these methods discussing among other issues model complexity, relevance to biology, ability to deal with hidden variables and scalability. I will also plead for the construction of a benchmark repository devoted to examples of relevant test problems even if the true relevant test has always to be made in vivo or in vitro.
| Slides | |
| 0:00 | Statistical learning of biological networks: a brief overview |
| 0:49 | Biological networks |
| 2:29 | Motivation |
| 3:14 | How to learn biological networks from data? |
| 5:59 | Learning (biological) networks |
| 10:55 | Outline - 1 |
| 11:28 | Supervised learning of the concept of regulation |
| 14:23 | Supervised learning of interactions |
| 14:52 | Supervised prediction of protein-protein interaction network |
| 15:41 | Similarity or kernel learning |
| 16:52 | Network completion and function prediction for yeast data |
| 18:08 | Challenges and limitations in supervised predictive approaches |
| 20:37 | Outline - 2 |
| 20:38 | Graphical models : from simple interactions models to complex ones |
| 21:40 | Focus on state-space models |
| 22:10 | System of Ordinary Differential Equations (ODE) |
| 22:12 | Focus on state-space models |
| 22:21 | System of Ordinary Differential Equations (ODE) |
| 22:22 | Reverse engineering of biological networks - 1 |
| 22:23 | Reverse engineering of biological networks - 2 |
| 23:00 | Challenges in (dynamical) modeling approaches |
| 24:42 | General conclusion and perspective |
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