Sculpting Implants in situ: Light-Adjustable Intraocular Lens
Description
Ko se naše očesne leče z leti starajo, se pogosto razvije očesna mrena. Vsako leto se opravi preko 14 milijonov operacij, kjer se očesna mrena odstrani in se vsadijo umetne leče. S trenutno uveljavljenimi lečami še vedno tretjina pacientov z očesno mreno po posegu potrebuje očala za optimalen vid. Da bi dosegli željeni cilj brez dodatnih korekcij, bi morale biti leče sposobne prilagoditve po končani terapiji. Novi materiali, ki so jih razvili na Caltech inštitutu, omogočajo post-operativne neinvazivne korekcije leč. V predavanju bo profesor Julia Kornfield predstavila skupne raziskave s prof. Bob Grubbsom iz Odseka za kemijo in očesnim kirurgom prof. Dan Schwartzem iz UCSF. Skupaj so razvili material, ki omogoča in vivo prilagoditve leč. Svetlobno-prilagodljive leče so se izkazale za uspešne v kliničnih testih saj so rezultati ponovljivi in napovedljivi.
| Slides | |
| 0:00 | Sculpting Implants in situ: Light-Adjustable Intraocular Lens |
| 3:48 | Motivation |
| 6:19 | Clinical Need |
| 6:45 | Design Principles for New Polymers |
| 10:24 | Light-induced changes in shape and refractive index |
| 13:36 | Simple Characterization of Lenses |
| 15:21 | Example of Power Change |
| 16:11 | Adjustments occur Overnight |
| 17:06 | Biocompatibility of Material & Irradiation: in vivo evaluation in rabbit |
| 17:33 | Adjustments in vivo are Precise and Predictable |
| 18:53 | Precise Myopic, Hyperopic & Astigmatic Adjustments |
| 19:42 | Clinical Implementation |
| 20:29 | Digital Mirror Device Projects Any Desired Intensity Profile |
| 21:17 | It works in rabbits, but does it work in people? |
| 22:33 | Results in Clinical Trials |
| 23:14 | Arbitrary Wavefront Correction |
| 24:07 | Restoring Distance & Near Vision |
| 25:45 | Strategies for “Built-in Bifocals” |
| 26:58 | Irradiate to Add Multiple Zones |
| 28:06 | Irradiate to Add a Diffractive Lens |
| 28:17 | USAF Target Images |
| 29:20 | Irradiation Patterns |
| 30:14 | Predicting Shape Change: Is this a previously solved problem? |
| 31:23 | Some Interesting Features |
| 33:09 | Diffusion and Deformation in Polymeric Gels |
| 35:18 | Important Processes |
| 36:55 | Important Processes: Relevant Parameters |
| 38:52 | Inter-Relationships among the Processes |
| 42:50 | Conclusions & Future Directions |
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