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Sculpting Implants in situ: Light-Adjustable Intraocular Lens

author: Julie A. Kornfield, California Institute Technology

Description

Ko se naše očesne leče z leti starajo, se pogosto razvije očesna mrena. Vsako leto se opravi preko 14 milijonov operacij, kjer se očesna mrena odstrani in se vsadijo umetne leče. S trenutno uveljavljenimi lečami še vedno tretjina pacientov z očesno mreno po posegu potrebuje očala za optimalen vid. Da bi dosegli željeni cilj brez dodatnih korekcij, bi morale biti leče sposobne prilagoditve po končani terapiji. Novi materiali, ki so jih razvili na Caltech inštitutu, omogočajo post-operativne neinvazivne korekcije leč. V predavanju bo profesor Julia Kornfield predstavila skupne raziskave s prof. Bob Grubbsom iz Odseka za kemijo in očesnim kirurgom prof. Dan Schwartzem iz UCSF. Skupaj so razvili material, ki omogoča in vivo prilagoditve leč. Svetlobno-prilagodljive leče so se izkazale za uspešne v kliničnih testih saj so rezultati ponovljivi in napovedljivi.

Categories

Top: Medicine

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Slides
0:00 Sculpting Implants in situ: Light-Adjustable Intraocular Lens
3:48 Motivation
6:19 Clinical Need
6:45 Design Principles for New Polymers
10:24 Light-induced changes in shape and refractive index
13:36 Simple Characterization of Lenses
15:21 Example of Power Change
16:11 Adjustments occur Overnight
17:06 Biocompatibility of Material & Irradiation: in vivo evaluation in rabbit
17:33 Adjustments in vivo are Precise and Predictable
18:53 Precise Myopic, Hyperopic & Astigmatic Adjustments
19:42 Clinical Implementation
20:29 Digital Mirror Device Projects Any Desired Intensity Profile
21:17 It works in rabbits, but does it work in people?
22:33 Results in Clinical Trials
23:14 Arbitrary Wavefront Correction
24:07 Restoring Distance & Near Vision
25:45 Strategies for “Built-in Bifocals”
26:58 Irradiate to Add Multiple Zones
28:06 Irradiate to Add a Diffractive Lens
28:17 USAF Target Images
29:20 Irradiation Patterns
30:14 Predicting Shape Change: Is this a previously solved problem?
31:23 Some Interesting Features
33:09 Diffusion and Deformation in Polymeric Gels
35:18 Important Processes
36:55 Important Processes: Relevant Parameters
38:52 Inter-Relationships among the Processes
42:50 Conclusions & Future Directions

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