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Self-organizing principles in branching morphogenesis
Published on May 23, 20181523 Views
The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macro-scopic features of branched org
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Chapter list
Self-organizing principles in branching morphogenesis00:00
Branching morphogenesis occurs at multiple settings and scales02:10
Are there generic/common morphogenetic rules?03:54
Intrinsic blueprints vs. self-organization in development?04:50
Turing mechanism for self-organized patterns 06:00
How is branched organ structure encoded genetically? - 108:13
How is branched organ structure encoded genetically? - 209:31
How is branched organ structure encoded genetically? - 310:53
How is branched organ structure encoded genetically? - 413:06
How do cells (self-)organise into complex organs?13:51
Branching dynamics during mammary development - 114:57
Mammary morphogenesis is non-stereotypical16:20
Branching dynamics during mammary development - 216:52
Branching and annihilating random walk (BARW) - 119:56
Branching and annihilating random walk (BARW) - 222:23
Simulations on a finite 2D rectangular domain22:53
Branching and annihilating random walk (BARW) - 323:40
Duct-dependent inhibition allows for self-organized travelling wave of invading tips25:56
Dynamics and self-organization during growth26:07
The model predicts the final mammary gland architecture with high accuracy - 126:31
The model predicts the final mammary gland architecture with high accuracy - 228:03
The model predicts the final mammary gland architecture with high accuracy - 329:25
Theory predictions on the kinetics on mammary invasion - 130:14
Theory predictions on the kinetics on mammary invasion - 232:02
Theory predictions on the kinetics on mammary invasion - 332:25
Theory predictions on the kinetics on mammary invasion - 433:05
Robustness of the annihilating random walks as a patterning mechanism - 133:54
Robustness of the annihilating random walks as a patterning mechanism - 234:36
Giant density fluctuationsin the mouse mammary gland - 135:26
Giant density fluctuationsin the mouse mammary gland - 236:01
Subtrees compete spatially37:41
What are the “macroscopic” rules? - 138:20
What are the “macroscopic” rules? - 239:49
Branching and annihilating random walks (BARW) - 440:46
Dimensionality of the branching and annihilating random walk 41:43
Can the same theory explain the kidney 3D branching morphogenesis? - 142:32
Can the same theory explain the kidney 3D branching morphogenesis? - 242:55
Dimensionality of the random walk predicts outcome43:55
Can the same theory explain the kidney 2D branching morphogenesis?45:30
How general are BARWs in biology? - 147:10
How general are BARWs in biology? - 247:55
Acknowledgments50:21
PhD students and post-docs wanted! Thank you50:41
A quantitative self-organised model of branching morphogenesis51:08