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Macroevolution: The roots of good and evil go deep in time
Published on 2015-02-033102 Views
Although the molecular nature of tumours is well studied in vertebrates, their evolutionary origin remains unknown. In particular, there is no evidence for naturally occurring tumours in pre-bilateria
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Presentation
Macroevolution00:00
Three stories00:24
Article01:22
The signing of the National Cancer Act of 197102:11
Diminishing Returns of Cancer Research02:46
1 Still dangerous03:53
National Cancer Institute04:31
Cancer05:27
Macroevolutionary origin of cancer - 106:12
Macroevolutionary origin of cancer - 207:08
Couldall animals develop tumors?07:33
...literature is not very informative07:48
Literature08:23
H. ogliactis - 109:14
H. ogliactis - 210:02
H. ogliactis - 310:21
Nanos11:50
Global expression divergence12:10
Tumorcells to invade at increased rates13:25
Differentiation arrest14:49
Model15:45
Are Hydratumors a disease?16:31
Microscopic View18:28
Conclusions –bona fidetumors in cnidarians - 119:01
Conclusions –bona fidetumors in cnidarians - 219:08
Conclusions - 119:55
Conclusions - 220:25
Conclusions - 320:53
Phylostratigraphic profiles in zebrafish uncover chordate origins of the vertebrate brain21:59
Vertebrate head22:37
Origin of the vertebrate brain? - 123:26
Origin of the vertebrate brain? - 224:06
Origin of the vertebrate brain? - 324:26
Origin of the vertebrate brain? - 424:58
Origin of the vertebrate brain? - 525:22
Genomic phylostratigraphy - 126:18
Genomic phylostratigraphy - 226:59
Genomic phylostratigraphy - 327:02
Hypothetical phylostratigraphic map - 127:08
Hypothetical phylostratigraphic map - 227:36
Statistics on the map28:27
Phylostrat software - 128:30
Phylostrat software - 228:59
Phylostrat software - 329:12
Phylostrat software - 429:34
Forebrain29:48
Pallium(cerebral cortex) - 129:59
Pallium(cerebral cortex) - 230:18
The adaptive landscape of the zebrafishCNS30:43
Conclusion - 131:12
Conclusion - 231:21
Parker 2003 -Light switch theory32:02