Exploring high‐content screening as a functional genomics tool in biomedicine
Slides
Related content
Report a problem or upload files
If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Description
High-content phenotypic screening, encompassing both drug and genomic screenings, constitute an invaluable research and discovery tool, which has been extensively explored by the industry and academia for various aims, including target discovery and validation, drug discovery and development, drug repurposing/repositioning, and mechanistic studies. In particular the application of functional genomic screenings using genome-wide RNAi, CRISPR and microRNA libraries in complex cell-based assays offers a unique opportunity to systematically probe the function of classical drug targets as well as of otherwise undruggable targets, enabling the investigation of molecular networks underlying complex biological and disease-relevant processes. Through the application of large-scale image-based screening approaches, we have been identifying and characterizing novel cellular factors (proteins and microRNAs) and drugs implicated in different biological contexts and pathologies, including cardiovascular disorders, infection and tumorigenesis. Overall, these studies have uncovered unexpected molecular players and pathways, revealing novel opportunities for therapeutic intervention.
Link this page
Would you like to put a link to this lecture on your homepage?Go ahead! Copy the HTML snippet !
Reviews and comments:
This is an excellent article. Well written. Good comments all around. Thanks for the post. https://www.birminghamcarpetcare.com
Write your own review or comment: