|search externally:||Google Scholar, Springer, CiteSeer, Microsoft Academic Search, Scirus , DBlife|
Dr. Wiley was a pioneer in developing methods for the quantitative analysis of receptor dynamics in mammalian cells and published some of the first computer models of receptor regulation. He has been a major contributor to the field of receptor research, particularly with regard to the control of receptor distribution within cells. He joined Pacific Northwest National Laboratory in 2000 to develop a systems biology program to exploit the laboratory's unique capabilities in cell imaging, computational biology and high-throughput proteomics. Currently, he is Lead Biologist at EMSL, a U.S. Department of Energy national scientific user facility located at PNNL. His research interests are focused on understanding mechanisms of cell regulatory networks using both prokaryotic and eukaryotic model systems. This work also involves mapping cellular signal transduction networks and how these networks integrate information from multiple inputs. More recently, his work has focused on building predictive models of the EGFR autocrine circuit using a combination of proteomics, gene expression, biochemical and optical assays. This work requires the creation of a scalable computational infrastructure for integrating multidimensional data sets as well as development of the underlying analytical technologies.
Dr. Wiley is also leading the development of a Systems Microbiology and Extremophile Research Facility in the EMSL that will provide the scientific community access to the technologies needed for systems biology research on microbial systems.
Academic Perspectives/Panel Discussion
as author at MIT Industrial Liaison Program,
together with: Douglas Lauffenburger (moderator), James Cassatt, Leroy Hood, Huntington Willard, Marc W. Kirschner, George Poste, Matthew P. Scott, Peter Sorger, David Botstein,