Gaussian Process Model for Inferring the Regulatory Activity of Transcription Factor Proteins
author:
Guido Sanguinetti,
Department of Molecular Biology and Biotechnology, University of Sheffield
Description
Inferring the concentration of transcription factors' proteins from the expression levels of target genes is a very active area of research in computational biology. Usually, the dynamics of the gene expression levels are modelled using differential equations where the transcription factor protein concentrations are treated as parameters, subsequently estimated using MCMC. We show how this inference problem can be solved more elegantly by placing a GP prior over the latent functions, obtaining comparable results to the standard MCMC approach in a fraction of the time.
You might be experiencing some problems with Your Video player.
SEE ALSO:
Lecture rating
| People found this lecture: | ||
| Worth seeing | ||
| because it is: | ||
| Valuable and informative | ||
| Well presented | ||
| Easily understandable | ||
| Acceptably recorded | ||
| You need to login to cast your vote. | ||
Report a problem or upload files
If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Link this page
Would you like to put a link to this lecture on your homepage?Go ahead! Copy the HTML snippet !



