Structural insights into NLP binding to plant membranes

author: Tea Lenarčič, National Institute of Chemistry Slovenia
published: Nov. 27, 2018,   recorded: November 2018,   views: 419
Categories

Slides

Related Open Educational Resources

Related content

Report a problem or upload files

If you have found a problem with this lecture or would like to send us extra material, articles, exercises, etc., please use our ticket system to describe your request and upload the data.
Enter your e-mail into the 'Cc' field, and we will keep you updated with your request's status.
Lecture popularity: You need to login to cast your vote.
  Bibliography

Description

Necrosis and ethylene-inducing peptide 1 (Nep1)-like proteins (NLPs) are secreted by several phytopathogenic micro-organisms. They trigger leaf necrosis and immunity-associated responses in various dicotyledonous plants. We identified glycosylinositol phosphorylceramides (GIPC), a major class of plant sphingolipids, as target molecules for NLP binding to plasma membranes. X-ray crystallography revealed that NLP forms complexes with terminal hexose moieties. NLP binding to GIPC head groups induces several conformational changes within the toxin that precedes membrane attachment and host cell lysis. This study unveils early steps of NLP cytolysin action and explains why dicot plants are NLP toxin-sensitive whereas monocot plants are not.

Link this page

Would you like to put a link to this lecture on your homepage?
Go ahead! Copy the HTML snippet !

Write your own review or comment:

make sure you have javascript enabled or clear this field: