Generative Models for Decoding Real-Valued Natural Experience in FMRI
Description
Functional Magnetic Resonance Imaging (FMRI) provides an unprecedented window
into the complex functioning of the human brain, typically detailing the activity
of thousands of voxels for hundreds of time points. The interpretation of FMRI
is complicated, however, because of the unknown connection between the hemodynamic
response and neural activity, and the unknown spatiotemporal characteristics
of the cognitive patterns themselves.
Recent work has exploited techniques from machine learning to find patterns of
voxel activity related to brain processes (see e.g., [1]). Many of these techniques
involve decoding, inferring the value or category class of a stimulus !S given a pattern
of voxel activations !V . Decoding can generally be split into two approaches, discriminative
and generative [2]. With a discriminative model one learns the conditional
distribution P(!S |!V ) directly by minimizing a loss such as minimum classification
error. Alternatively, the generative approach obtains this conditional probability
through Bayes rule; one posits and fits models for P(!S ) and P(!V |S) instead. Both
approaches can reliably establish the existence of sufficient decoding information.
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