0.25
0.5
0.75
1.25
1.5
1.75
2
RNA toxicity in a zebrafish model for C9orf 72 ALS is abrogated by Pur-alpha and p62
Published on Jul 21, 2017936 Views
A repeat expansion in the C9orf72 gene is the most frequent cause of ALS. This repeat expansion is believed to be neurotoxic because of (a combination of) direct RNA toxicity, DPR toxicity or loss
Related categories
Chapter list
RNA toxicity in a zebrafish model for C9orf 72 ALS is abrogated by Pur-alpha and p6200:00
Background00:08
Is repeat RNA toxic in zebrafish? 01:22
Are DPRs toxic in zebrafish?02:17
Can repeat RNA toxicity be caused by DPR toxicity? - 102:48
Can repeat RNA toxicity be caused by DPR toxicity? - 204:54
Can repeat RNA toxicity be modified?06:17
p62 in RNA toxicity zebrafish model?07:18
What is the mechanism of the rescue by Purα? 08:35
What is the mechanism of the rescue by Purα? – PUR2 domain09:10
What is the mechanism of the rescue by Purα? – G-rich domain10:05
Summary10:32
Acknowledgments11:16