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The time of the ALSFRS-R to decrease to 50% (D50) in a sigmoidal decay model sufficiently describes the complete disease course of ALS
Published on Jul 21, 20171568 Views
Introduction: Deterioration in ALS is not linear but this is what the routinely used progression rate [PR = (48-ALSFRS-R/disease duration)] suggests, as it describes progression at a circumscribed t
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Chapter list
The time taken by the ALSFRS-R to decrease to 50% (D50) in a sigmoidal decay model sufficiently describes the disease course of amyotrophic lateral sclerosis 00:00
ΔFRS and Progression; how much can it really tell us?00:34
No established threshold01:38
Presumes linearity 02:19
Circumscribed time point02:50
Capture and Describe Disease Course - 103:25
Capture and Describe Disease Course - 204:00
How does ALSFRS-R frequency affect model robustness?04:47
Real patient data: “fast”, “intermediate” and “slow” progressors - 105:38
Real patient data: “fast”, “intermediate” and “slow” progressors - 206:33
Potential for Phase Classification07:15
D50 and Contemporary Staging Systems07:50
Key Takeaways09:39
Utility and Implementation11:12
Open Questions and Further Directions12:46
Acknowledgements13:58