Principle of Systems Biology illustrated using the Virtual Heart
author:
Denis Noble,
Department of Physiology, Anatomy & Genetics, University of Oxford
Description
Highest systems property: “The living organism does not really exist in the milieu extérieur but in the liquid milieu intérieur … a complex organism should be looked upon as an assemblage of simple organisms … that live in the
liquid milieu intérieur.”
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| Slides | |
| 0:00 | The principles of Systems Biology illustrated using the virtual heart |
| 1:09 | ? Systems Biology ? |
| 2:32 | Publication of Claude Bernard‘s classic Introduction à l’étude de la médecine expérimentale |
| 2:40 | Highest systems property |
| 3:24 | On mathematics |
| 4:32 | On mathematics - but |
| 4:53 | The problem we face today both resembles that faced by Bernard and differs from it. |
| 6:20 | Some principles of Systems Biology - Biological functionality is multi-level - part 1 |
| 7:12 | Some principles of Systems Biology - Biological functionality is multi-level - part 2 |
| 7:42 | Some principles of Systems Biology - Biological functionality is multi-level - part 3 |
| 8:56 | Some principles of Systems Biology - Biological functionality is multi-level - part 4 |
| 9:09 | Some principles of Systems Biology - Transmission of information is NOT one-way |
| 10:33 | The reductionist causal chain |
| 11:54 | Selfish Genes |
| 13:23 | Genes as Prisoners |
| 14:56 | Unravelling complexity |
| 15:49 | Example of protein interaction in a cell model Reconstructing the heart’s pacemaker |
| 20:11 | Some principles of Systems Biology - DNA is NOT the sole transmitter of inheritance - part 1 |
| 21:54 | Some principles of Systems Biology - DNA is NOT the sole transmitter of inheritance - part 2 |
| 22:12 | Some principles of Systems Biology - DNA is NOT the sole transmitter of inheritance - part 3 |
| 22:22 | Some principles of Systems Biology - DNA is NOT the sole transmitter of inheritance - part 4 |
| 24:26 | Some principles of Systems Biology - Theory of (biological) Relativity |
| 25:19 | Some principles of Systems Biology - Gene ontology will fail without higher-level insight |
| 27:31 | Some principles of Systems Biology - There is no ‘genetic program’ |
| 29:49 | Peter Hunter –the Auckland model ventricle |
| 30:27 | Spread of excitation wave in whole ventricle model |
| 30:44 | Impact-induced arrhythmia |
| 31:49 | Breakdown of re-entrant arrhythmia into fibrillation |
| 32:27 | Human cell model |
| 32:42 | Re-entrant arrhythmia in human model |
| 33:05 | Some principles of Systems Biology - There are no programs at any other level |
| 34:26 | Some principles of Systems Biology - No programs at any level –including the brain! - part 1 |
| 34:54 | Some principles of Systems Biology - No programs at any level –including the brain! - part 2 |
| 35:26 | Some principles of Systems Biology - No programs at any level –including the brain! - part 3 |
| 36:04 | Some principles of Systems Biology - The self is an integrative process not an object or substance |
| 36:43 | Some principles of Systems Biology - There are many more to be discovered! |
| 37:41 | Concluding remarks |
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Very good and refreshing!
The questions at the end are worth listening. The lecture is very philosophical but it makes a point.
Great lecture. I like his point on metaphors. However, I find funny how he says that non-dualistic philosophies (no right and wrong) are right.
Interesting critique of Richard Dawkins' genecentric view of Biology. I think it is possible that because Dawkins is aiming at a mass audience he adopts metaphor and perhaps takes it beyond the point where it is truly valid for the sake of not confusing the lay person. Noble is targeting a much more sophisticated audience and so doesn't have to compromise the complexity. Another way of viewing Noble's position is that he is trying to reassert the status of Physiology as a discipline after it has suffered because of the explosion in molecular biology, genomics, bioinformatics etc. He is completely correct that the end point of the reductionist approach has to be able to recreate the system in model form. If you can do that and replicate all of its behaviours this is the only way you can know that you truly understand it. This is the future of physiology - to integrate all of the molecular and cellular information back to the organ (and ultimately whole body) level.