Folding Funnels in Energy Landscapes

author: Konstantin Klemm, Bioinformatics, University of Leipzig

Description

Local minima and the saddle points separating them in the energy landscapeare known to dominate the dynamics of biopolymer folding. Here weintroduce a notion of a 'folding funnel' that is concisely defined interms of energy minima and saddle points, while at the same time conformingto a notion of a 'folding funnel' as it is discussed in the protein foldingliterature.

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*Slides*
0:00	Folding funnels in energy landscapes
0:49	Protein folding - part 1
2:46	Protein folding - part 2
3:54	Dynamics on a discrete landscape
5:00	Average time to target
5:57	Time to target in one dimension
8:15	Intuitive description of a funnel
9:40	Geometric definition of a funnel
10:15	Funnel in a rugged random landscape
12:08	Funnels of a bistable RNA molecule part 1
13:16	Funnels of a bistable RNA molecule - part 2
15:00	Summary

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