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Algorithms in Complex Systems
Pascal

Adaptive procedures for FDR control in multiple testing

author: Gilles Blanchard, Fraunhofer FIRST

Description

Multiple testing is a classical statistical topic that has enjoyed a tremendous surge of interest in the past ten years, due to the growing domain of applications that are in demand for powerful and reliable procedures to this regard. For example, in bioinformatics it is often the case that multiple testing procedures are needed to process data in very high dimension where only a small number of sample points are available. In their 1995 seminal work, Benjamini and Hochberg first introduced the false discovery rate (FDR), a notion of type I error control that is particularly well suited to screening processes where a very high number of hypotheses has to be tested. It has since then been recognized as a de facto standard. We first review existing so-called "step-up" testing procedures with FDR control valid under several types of dependency assumptions on the joint test statistics, and show that we can recover (and extend) them by considering a very simple set-output point of view along with with what we call a "self-consistency condition" which is sufficient to ensure FDR control. We then proceed to consider adaptive procedures, where the estimation of the total proportion of true null hypotheses can lead to improved power. To this regard we introduce an algorithm that is almost always more powerful than an adaptive procedure proposed by Benjamini, Yekutieli and Krieger (2006).

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Slides
0:00 Adaptive procedures for FDR control in multiple testing
0:20 Plan
1:44 - Multiple testing
1:46 Introduction - 1
2:28 Introduction - 2
2:48 Single testing procedure - 1
3:43 Single testing procedure - 2
4:56 p-values for single hypothesis testing - 1
6:01 p-values for single hypothesis testing - 2
7:36 Multiple testing - 1
8:11 Multiple testing - 2
8:35 Multiple testing - 3
9:07 Multiple testing - 4
9:41 Multiple testing - 5
9:59 Mathematical setting for multiple testing - 1
11:24 Mathematical setting for multiple testing - 2
12:44 What quantification for the type I error? - 1
13:58 What quantification for the type I error? - 2
14:38 FDR and screening processes
16:41 - FDR control from a set-output point of view
16:51 A “self-consistency” condition - 1
18:57 A “self-consistency” condition - 2
20:40 FDR control under (SC)
22:54 Different cases - 1
25:57 Different cases - 2
26:48 - Questions
28:15 Step-up procedures - 1
29:43 Step-up procedure - 2
30:43 Different cases - 3
30:54 Role of shape function β - 1
32:35 Role of shape function β - 2
33:16 Examples
36:06 - Adaptive procedures
36:10 Adaptivity to |H0| - 1
37:24 Adaptivity to |H0| - 2
38:42 Existing procedures
40:33 New one-stage adaptive procedure for independent test statistics
41:45 Comparison to LSU (α = 0.1)
42:28 New two-stage adaptive procedure for independent test statistics
42:57 Comparison to LSU (α = 0.1)
43:03 New two-stage adaptive procedure for independent test statistics
43:42 Comparison on simulations
44:32 Power (independent case ρ = 0)
45:56 FDR (positive correlation case ρ = 0.5)
47:35 Adaptive procedure under unspecified dependencies
48:25 FDR (positive correlation case ρ = 0.5)
48:30 Adaptive procedure under unspecified dependencies
50:27 Conclusion and perspectives

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