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Chemistry and biology of aging and age-related diseases
Published on Dec 09, 2017749 Views
Proteins carry on, directly or indirectly, all life activities and are subject to oxidative damage. Ever since the increase in atmospheric oxygen from about 1 to 21%, accompanied by the shift from ana
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Chapter list
MedILS00:00
Future Mediterranean Institute for Life Sciences in 200306:16
Picture07:06
Picture - 107:17
Picture - 207:30
Picture - 307:58
Picture - 408:31
Picture - 508:37
Biology of aging and age-related diseases08:43
All things are difficult before they are easy13:14
Delaying destiny13:44
Delaying destiny - 115:20
Ros15:52
Ros, protein damage and its impact16:02
Mutator phenotype of chaperone deletions depends on high oxidative damage to misfolded proteins21:14
Sketched « Krisko Plots »24:18
Cellular functional degeneracy, aging and death by proteome oxidation26:22
Performance of genetically identical individuals, of the same age, in an identical environment27:17
Aging and diseases are reversible28:09
Accelerated ageing correlates with accelerated carbonylation29:32
A small fraction of human proteins are oxidable – most are “inox”!30:08
The Causes of Protein Carbonylation31:22
Competitive Antagonism between Folding and Oxidation33:23
Fixed protein errors - example35:00
"Silent"polymorphims at young age becomes "loud" at old age36:05
Inborn syndromes37:37
Cellular parabiosis, cancer latency and tumour promotion38:17
Revealing latent recessive phenotypes38:54
Specific Metabolic rate vs. Body mass40:21