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The magic of DNA, the molecule of life and its structures
Published on Apr 13, 20182021 Views
Deoxyribonucleic acid, DNA, is known by a series of nucleotides that carry genetic instructions used in the growth, development, functioning and reproduction of all known living organisms and many vir
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The magic of DNA, the molecule life and its structures - 100:00
The magic of DNA, the molecule life and its structures - 204:29
The magic of DNA, the molecule life and its structures - 304:54
The magic of DNA, the molecule life and its structures - 405:09
The magic of DNA, the molecule life and its structures - 505:16
The magic of DNA, the molecule life and its structures - 605:21
The magic of DNA, the molecule life and its structures - 705:28
Slovenian NMR Centre06:02
Chemical shift09:02
Studies of structure and dynamics biomolecules12:25
Research program12:48
International events14:22
DNA - double-helix, Watson-Crick base pairs, ... - 115:01
DNA - double-helix, Watson-Crick base pairs, ... - 217:08
Guanine nucleos (t) ides17:50
Guanine - quadruplexes 19:46
Connecting loops21:49
Loop orientations orientations in G-quadruplexes22:26
G-quadruplex (es) in telomeric ends - 124:02
G-quadruplex (es) in telomeric ends - 226:41
Prevalence of quadruplex motifs in the human genome - 127:19
Prevalence of quadruplex motifs in the human genome - 229:14
Prevalence of quadruplex motifs in the human genome - 329:46
The importance of cations30:12
Polymorphism of human telomer repeat 31:44
Power of NMR in structural elucidation32:20
A four repeat human telomere sequence33:15
Folding process33:51
Folding of htel134:28
Unambiguous assignment of imino protons - 134:49
Unambiguous assignment of imino protons - 236:12
Topology of TD form36:34
Identification of another form of htel1-ΔG2336:59
Unambiguous assignment of KDH + form37:16
Donor / acceptor directionality of H-bonds38:14
CD signatures and thermal stability38:56
Comparison of both topologies 39:27
Populations of TD and KDH+forms39:55
Proto-oncogene c-myc40:58
Visualisation of G-quadruplexes41:29
Titration with DAOTA-M242:27
Binding of ligand DAOTA-M2 with G-quadruplex42:47
Binding model42:57
Structure of DAOTA-M2 with G-quadruplex43:04
d (GCGAGGG) repeats - 143:06
d (GCGAGGG) repeats - 243:45
Possible folds adopted 43:55
Folding in the presence of Li + cations44:31
Sequential assignment - 144:34
Sequential assignment - 244:39
High-resolution structure of VK1 - 144:42
High-resolution structure of VK1 - 245:07
High-resolution structure of VK1 - 345:11
High-resolution structure of VK1 - 445:12
Fingerprints in NOESY spectra45:49
A16 connects A16 ‘two units‘ of the monomeric fold45:52
d (GCGAGGG) repeats - 346:11
What is the structure of VK34? 46:13
Dimeric structure - 146:19
Dimeric structure - 246:27
Dimeric and monomeric folds46:57
AGCGA repeats in the genome47:09
Summary and Implications48:06
Thank you49:48