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Edinstvene strukturne lastnosti monomernega in dimernega Gkvadrupleksa, v katera se zvije zaporedje iz introna gena N‐myc
Published on Jan 17, 20141614 Views
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Edinstvene strukturne lastnosti monomernega in dimernega G-kvadrupleksa, v katera se zvije zaporedje iz introna N-myc00:00
DNA - double-helix, Watson-Crick base pairs, ...00:20
Guanine nucleos(t)ides01:30
G-quartets02:28
Polymorphism of d[AGGG(TTAGGG)3]:The role of cations03:00
Prevalence of quadruplex motifs in the human genome05:29
Nuclear Magnetic Resonance: Chemical shift06:42
1H NMR spectrum of d(TAG3CG3AG3AG3A2) in 90% H2O - 107:06
1H NMR spectrum of d(TAG3CG3AG3AG3A2) in 90% H2O - 207:20
Monomeric structure07:32
d(TAG3CG3AG3AG3A2) at higher concentrations07:54
Translational diffusion coefficient08:09
Dimeric G-quadruplex from intron of mycN08:26
Equilibrium09:43
Folding of d(TAG3CG3AG3AG3A2 ) in the presence of Na+ ions10:28
Conclusions10:59
Acknowledgments11:47