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The tricks neurons use to express their genes: jumping genes, zero-length exons and RNA loops

Published on Feb 4, 20251413 Views

As soon as DNA is transcribed into RNA, various RNA-binding proteins (RBPs) interact with the RNA, and thereby regulate the expression of proteins. This is particularly important in highly polarised c

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The tricks neurons use to express their genes00:00
How are RNAs important for gene expression in neurons?41:04:56
Measure interactions93:46:26
Zero-length exons134:38:26
Splicing makes an mRNA - 1147:09:36
Splicing makes an mRNA - 2151:37:36
Recursive splicing makes same mRNA - 1153:11:46
Recursive splicing makes same mRNA - 2157:22:26
Recursive splicing makes same mRNA - 3159:30:16
Recursive splicing makes same mRNA - 4160:27:46
Genes expressed in the brain are extremely long165:32:26
Recursive splice sites are present within some of the longest genes180:46:26
Definition of the cryptic exon is required for recursive splicing201:48:56
Recursive sites are followed by cryptic poison exons243:47:36
Recursive site prevents inclusion of the cryptic exon260:35:46
Suggested model for the mechanism of recursive splicing in vertebrates - 1280:02:26
Suggested model for the mechanism of recursive splicing in vertebrates - 2282:57:06
Suggested model for the mechanism of recursive splicing in vertebrates - 3284:11:44
Suggested model for the mechanism of recursive splicing in vertebrates - 4285:23:43
Suggested model for the mechanism of recursive splicing in vertebrates - 5286:49:02
The cryptic exon is included if preceded by another cryptic exon289:42:22
Recursive splicing detects upstream cryptic exons - 1318:40:58
Recursive splicing detects upstream cryptic exons - 2321:39:08
Recursive splicing detects upstream cryptic exons - 3323:58:18
Recursive splicing detects upstream cryptic exons - 4329:27:48
Cryptic exon detects other cryptic exons due to recursive splicing334:14:58
Gene353:33:48
Jumping genes362:01:08
Formation of exons from antisense Alu elements376:25:08
hnRNP C represses splicing of Alu exons413:13:08
Alu exons can cause human diseases439:19:38
hnRNP C controls the emergence of Alu-derived cryptic exons460:25:08
hnRNP C represses damaging cryptic Alu exons483:34:28
Het489:02:28
RNA loops510:05:08
hiCLIP511:21:48
mRNAs have a structure to form mRNPs524:22:28
Example 1: RNA structures can act as thermometers558:18:28
RNA duplexes in 3’ UTR lead to formation of long RNA loops572:50:27
Long-range RNA duplexes are not computationally predicted590:43:06
STAU1 regulates cytoplasmic splicing of the XBP1 mRNA608:36:25
RBPs regulate the time and space of neuronal gene expression649:07:45
Thanks to - 1669:43:05
Thanks to - 2695:57:05