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Chronic social isolation reduces parvalbumin-positive interneurons in the medial prefrontal cortex of adult rats: protection by fluoxetine and clozapine
Published on Oct 01, 20151545 Views
Depression is one of the leading causes of disability worldwide. Recent studies have indicated that there is a link between depressive symptoms and disregulation of GABAergic system. Decrement of parv
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Chapter list
Chronic social isolation reduces the parvalbumin-positive interneurons in the medial prefrontal cortex of adult rats: protection by fluoxetine and clozapine00:00
Depression – the silent epidemic00:46
GABAergic system dysfunction in mood disorders02:19
Parvalbumin (PV) – positive interneurons03:13
Goals03:45
Chronic social isolation stress04:17
Materials and methods - 105:26
Materials and methods - 206:58
Representative images of PV-positive interneurons in medial prefrontal cortex07:34
Number of PV-positive interneurons in PrCm region08:08
Number of PV-positive interneurons in Cg1 region08:53
Number of PV-positive interneurons in PrL region09:14
Number of PV-positive interneurons in IL region09:31
Number of PV-positive interneurons in DP region09:47
Discussion and conclusions - 110:12
Discussion and conclusions - 210:53
Thank you for your attention12:27