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Learning mechanisms of drug dependence
Published on 2015-09-071637 Views
The development of drug dependence relies heavily on an aberrant learning history. Initially, the experience of the drug itself is linked with environmental cues through a process of Pavlovian conditi
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Presentation
Learning mechanisms of drug dependence00:00
In this talk…00:57
Stages in drug addiction - 102:09
Development of a drug-seeking habit?02:58
Caudate putamen dopamine evoked by cocaine cues03:22
Stages in drug addiction - 203:54
Cocaine Self Administration in Rats04:40
Assignment of Incentive Salience - 106:38
Assignment of Incentive Salience - 207:50
A learning mechanisms involved in drug seeking08:25
The other dopamine pathway09:44
Working neurological model10:22
Circuitry recruitment10:45
Blocking DA receptors in the dorsal striatum - 111:04
Blocking DA receptors in the dorsal striatum - 211:47
Instrumental learning in addiction12:45
Prolonged training and the development of a S-R habit13:32
Cocaine seeking-taking chained schedule - 114:36
Cocaine seeking-taking chained schedule - 215:32
Conditioned Stimuli – Conditioned Reinforcers - 116:37
Conditioned Stimuli – Conditioned Reinforcers - 217:29
Needle Freaks17:39
Cue-exposure therapy - 118:45
Cue-exposure therapy - 219:05
Urge to use19:17
Extinction - 119:34
Extinction - 219:53
Extinction - 320:11
Cue-exposure therapy20:31
Threats to extinction22:02
Cue-exposure therapy - 323:27
Drug is more than reward or reinforcer24:16
Drug states as stimuli - 124:41
Drug states as stimuli - 224:49
Drug states as stimuli - 324:53
Drug can serve as an interoceptive CS25:01
Pavlovian Drug Discrimination - 125:10
Measure25:26
Pavlovian Drug Discrimination - 226:19
Nicotine Conditioned Stimulus26:48
Drug can act like an exteroceptive CS27:18
Compound Acquisition - 128:46
Compound Acquisition - 229:02
Element Testing29:07
Cue-exposure therapy - 430:05
Alcohol exposure therapy - 131:11
Alcohol exposure therapy - 232:00
Pharmacokinetic contributions - 132:48
Pharmacokinetic contributions - 234:04
Extinction - 434:50
In summary35:26
Acknowledgements36:01