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Deciphering the intricate role of intrinsically disordered regions in transcription factor regulation
Published on Jun 26, 202330 Views
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Deciphering the intricate role of intrinsically disordered regions in transcription factor regulation00:00
Disclosures - 100:39
Disclosures - 200:55
Disclosures - 301:47
Madl lab @ Medical University of Graz - 102:49
Madl lab @ Medical University of Graz - 203:15
Madl lab @ Medical University of Graz - 303:49
Hallmarks of Ageing - 105:47
Hallmarks of Ageing - 207:25
Disordered proteins are key players in ageing08:12
Our vision – deciphering and targeting key molecular mechanisms of ageing09:04
Intrinsically disordered proteins/regions have unique properties10:04
Intrinsically disordered proteins/regions are highly modified11:06
Disordered regions play key roles in import & LLPS11:58
Disordered regions play key roles in signaling - 112:26
Disordered regions play key roles in signaling - 212:52
FOXOs are master regulators13:27
The PI3K/PKB/FOXO module14:14
FOXOs are challenging for structural biology15:07
β-catenin binds FOXO4 disordered region - 116:11
β-catenin binds FOXO4 disordered region - 218:07
β-catenin binds FOXO4 disordered region - 318:47
β-catenin binds FOXO4 disordered region - 419:37
FOXO4 is phosphorylated at the CRPKB/AKT20:24
Phosphorylation blocks β-catenin binding22:07
FOXO4 is auto-inhibited - 122:32
FOXO4 is auto-inhibited - 223:37
FOXO4 is auto-inhibited - 324:12
In cell FRET confirms FOXO4 conformational change26:03
Auto-inhibition is conserved among FOXOs26:52
ICAT regulates FOXO4/TCF/LEF binding to β-catenin - 128:24
ICAT regulates FOXO4/TCF/LEF binding to β-catenin - 229:43
ICAT regulates FOXO4/TCF/LEF signaling32:11
b-catenin competes with FOXO autoinhibition - 133:10
b-catenin competes with FOXO autoinhibition - 234:23
b-catenin - FOXO interaction network35:13
Targeting disordered regions of transcription factors36:08
Here we are and there we go36:51