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Evolution of protein complexes and protein interaction networks
Published on Sep 07, 20076569 Views
There is an abundance of data on protein interactions and protein complexes, both from conventional smallscale experiments collected over the decades, including threedimensional structures, and mo
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Chapter list
Evolution of Protein Interactions in Networks and Complexes00:00
The question: How do protein interactions evolve? - part 102:13
The question: How do protein interactions evolve? - part 203:05
The question: How do protein interactions evolve? - part 305:42
Frequency in protein interaction networks?05:56
Frequency in protein interaction networks?07:23
Frequency in protein interaction networks?08:17
Outline - part 108:29
Outline - part 208:54
Echo and Narcissus09:45
How frequent are homo-oligomers?10:02
Selective advantages of homo-oligomers12:38
3Dcomplex.org - a hierarchical classification of complexes16:16
Abrief reminder of symmetry19:20
Evolutionary pathways of complex assembly22:17
Symmetries found in a non-redundant set of ~2500 complexes - part 124:57
Symmetries found in a non-redundant set of ~2500 complexes - part 225:52
Evolutionary pathways of complex assembly26:13
Outline26:16
Conservation of Quaternary Structure -Examples26:24
Conservation of Quaternary Structure27:29
Model of homomer evolution29:00
Homology to the largest interface is common29:56
An evolutionary relic31:32
Predictions based on largest interface32:00
A hypothesis: evolution predicts assembly pathway?32:33
Outline35:30
Macromolecular mass spectrometry (E.B. Erba & C.V. Robinson)35:46
Complexes with characterised assembly pathways -agreement with predictions37:19
Outline - Interface size and geometry as unifying principle38:34
Summary41:10
Acknowledgements41:56