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Stochastic estimation of fluxes in metabolic networks
Published on 2007-09-074873 Views
The qualitative and quantitative information conveyed by metabolic networks are important for regulating the metabolism of an organism to achieve desired targets. One approach to quantification is t
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Presentation
Stochastic Estimation of Fluxes in Metabolic Networks00:00
Overview00:26
Systems Biology01:39
Metabolic Systems01:57
Metabolic Network Map of E.coli[2]03:13
Metabolic Network Analysis04:04
Metabolic Flux Analysis05:55
Stoichiometric Equation08:17
Flux Balance Analysis08:52
13C Tracer based Flux Analysis10:44
MFA based on 13C Tracer Experiment13:29
Metabolic Flux Estimation16:40
Total Least Squares Estimation18:28
Cyclic Pentose Phosphate Pathwayand its 13C Enrichment Balance19:38
Least Squares Flux Estimates20:35
Linear least squares performance21:14
Nonlinear Least Squares Estimation22:23
Incomplete Data and Noise22:49
Maximum Likelihood Estimation24:25
Expectation Maximisation24:42
Expectation Conditional Maximisation25:29
Metabolic Flux Estimation by ECM26:10
Central metabolism of Corynebacterium glutamicum27:00
ECM Estimation Results27:15
ECM Algorithm Efficiency29:09
Incorporating Noise29:27
Bayesian Approach29:37