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Stochastic estimation of fluxes in metabolic networks
Published on Sep 07, 20074864 Views
The qualitative and quantitative information conveyed by metabolic networks are important for regulating the metabolism of an organism to achieve desired targets. One approach to quantification is t
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Chapter list
Stochastic Estimation of Fluxes in Metabolic Networks00:00
Overview00:26
Systems Biology01:39
Metabolic Systems01:57
Metabolic Network Map of E.coli[2]03:13
Metabolic Network Analysis04:04
Metabolic Flux Analysis05:55
Stoichiometric Equation08:17
Flux Balance Analysis08:52
13C Tracer based Flux Analysis10:44
MFA based on 13C Tracer Experiment13:29
Metabolic Flux Estimation16:40
Total Least Squares Estimation18:28
Cyclic Pentose Phosphate Pathwayand its 13C Enrichment Balance19:38
Least Squares Flux Estimates20:35
Linear least squares performance21:14
Nonlinear Least Squares Estimation22:23
Incomplete Data and Noise22:49
Maximum Likelihood Estimation24:25
Expectation Maximisation24:42
Expectation Conditional Maximisation25:29
Metabolic Flux Estimation by ECM26:10
Central metabolism of Corynebacterium glutamicum27:00
ECM Estimation Results27:15
ECM Algorithm Efficiency29:09
Incorporating Noise29:27
Bayesian Approach29:37