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Personal genomics in psychiatry - a personal view
Published on Jan 23, 20123770 Views
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Chapter list
Personal genomics in psychiatry - a personal view00:00
Human genetic code - deciphered00:51
Take two genes and call me in the morning01:49
The glass is ...02:21
Predicted Cumulative Freedom02:43
Symptoms (DSM-IV-TR)04:06
Some epidemiology05:29
How can we realize the promise of personalized antidepressant medicines?06:46
Outline06:59
Pharmacogenetics07:55
Heterogeneous Antidepressant Treatment Response Pattern07:57
ABCB109:35
Castle wall (barrier) function09:38
Citalopram10:40
Linkage disequilibrium (LD)11:55
Cox-Regression Survival Analysis - 112:25
Cox-Regression Survival Analysis - 213:29
Consequences14:24
Polymorphisms in the Drug Transporter Gene ABCB1 Predict Antidepressant Treatment Response in Depression15:04
Adding Linear Effects15:09
A Genomewide Associaion Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in Depression15:14
Heterogeneous Antidepressant Treatment Response Pattern15:21
Study design15:26
Multi-Locus Analysis – STAR*D predicted from MARS16:55
Epistasis18:18
Epistasis – basic idea18:28
Genome-wide analysis of epistasis20:03
Need for speed20:40
Basic idea20:48
Approximation21:45
Speedup via GPU computing22:58
EPIBLASTER-fast exhaustive two-locus epistasis detection strategy using graphical processing units23:35
Epistasis detection on quantitative phenotypes by exhaustive enumeration using GPUs23:48
Stimulation Data24:12
Heterogeneous Antidepressant Treatment Response Pattern24:33
Phenotype Distribution - % change after two weeksmars24:40
Phenotype25:48
Pair 127:27
Pair 229:33
Gene30:09
Pbx/Meis Deficiencies Demonstrate Multigenetic Origins of Congenital Heart Disease31:04
Going Beyond Genetics31:51
Not only genetics ... - 132:02
Not only genetics ... - 233:25
Disease prediction34:33
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment34:41
Patients with the TT genotype of rs1360780 respond faster to antidepressants34:56
FKBP5 and development of depression36:02
Interaction between rs3800373 and baseline adverse events on incident MDE36:14
Cumulative lifetime incidences of MDE by rs3800373 and lifetime severe trauma prior to baseline37:38
Desirables38:54
Desirables ...38:56
The glass has made a lateral move.40:11