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Inferring a measure of physiological age from multiple ageing related phenotypes
Published on Jan 23, 20124020 Views
What is ageing? One definition is simultaneous degradation of multiple organ systems. Can an individual be said to be “old” or “young” for their (chronological) age in a scientifically meaningful way?
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Chapter list
Inferring a measure of physiological age from multiple ageing related phenotypes00:00
Motivation (part 1)00:29
Motivation (part 2)01:57
Setting the scene03:16
Global systemic ageing04:40
Linear model05:51
This 55 year old individual has the nuclear dip of a 67 year old07:40
The same 55 year old individual has the telomeres of a 72 year old09:06
Delta vs. age - 109:37
Non-linear model - 110:59
Non-linear model - 211:45
Delta vs. age - 212:14
Delta vs. age - 313:16
Held out phenotype test13:26
Bayes factors15:54
Genes correlated with ageing16:40
Conclusions (part 1)18:37
Ongoing work19:32
Conclusions (part 2)21:16