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Biomacromolecules in controlled release and nanomedicine: poly (lactide-co-glycolide) micro and nanospheres
Published on Feb 06, 20123846 Views
Biomacromolecules such as poly (glycolic acid), poly (lactic acid), their copolymers and other polyesters have been used in a number of clinical applications. The major applications include drug deliv
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Biomacromolecules In Controlled Release And Nanomedicine: Poly (Lactide-Co-Glycolide) Micro And Nanospheres00:00
Nanomedicine00:14
Controlled drug delivery00:41
Biomacromolecules01:14
Poly / Ascorbic acid - 101:49
Poly / Ascorbic acid - 203:04
Particle with encapsulated medicament03:32
Overview - 104:06
Overview - 205:32
Shematics of obtaining poly05:59
The particle yield for various PLGA/ascorbic acid ratios06:45
Loading efficiency and loading amount of PLGA/ascorbic acid particles07:33
XRD patterns07:44
Content of ascorbic acid - 108:32
Content of ascorbic acid - 209:06
Comparative results of the stereological examining - 109:53
Comparative results of the stereological examining - 210:27
TEM images of ascorbic acid particles11:38
In vitro PLGA and PLGA/ascorbic acid degradation12:21
Release of the ascorbic acid12:54
SEM images of PLGA nanospheres13:22
SEM images of PLGA/ascorbic acid - 113:56
SEM images of PLGA/ascorbic acid - 214:19
SEM images of PLGA/ascorbic acid - 314:25
SEM images of PLGA nanospheres14:33
SEM images of PLGA /ascorbic acid - 415:03
SEM images of PLGA /ascorbic acid - 515:20
SEM images of PLGA /ascorbic acid - 615:26
In vitro / In vivo15:30
In vitro15:43
In vivo16:11
The radiochemical purity results17:20
Organ distribution data in Wistar rats18:12
Scheme of the synthesis of the PLGA/folic acid nanoparticles19:56
Graph of the linear relationship21:01
IR spectra of the PLGA21:55
SEM images of particles with different ratio of PLGA and folic acid22:22
Comparative results of the stereological study23:26
Zeta potential of PLGA dispersion without and with different concentration of folic acid24:01
Comparative curves24:24
Scheme of obtaining silver nanoparticles24:45
UV measurements25:23
The temperature effect26:10
Time dependant effect26:27
The FESEM measurements - 126:45
The FESEM measurements - 227:10
The FESEM measurements - 327:39
The FESEM measurements - 428:03
Induction of intracellular reactive oxygen species28:48
FESEM images of PLGA/AgNpPGAs spherical particles29:18
Horseradish peroxidase29:44
Shematic diagram of manufacturing process for HRP-loaded PLA spheres30:23
Graph of the linear relationship30:53
FESEM images of HRP-loaded PLA spheres prepared by modified precipitation method31:25
Stereological analysis of PLA-HRP spheres based on Dmax.31:47
Protein stability32:10
Summary32:27
References (2007-2011) - 134:12
References (2007-2011) - 234:16
Acknowledgements34:21
Thank you!34:27