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How to assess potential hazardous properties of nanomaterials: an example of TiO2
Published on Jun 08, 20113104 Views
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Chapter list
How to assess potential hazardous properties of nanomaterials: an example of TiO200:00
Why a concern?00:47
Sources of NPs01:17
Risk = f(hazard, exposure)01:36
The pillars of risk assessment02:15
Hazard identification06:39
Physical - chemical characterization06:50
How the surface area of a nano - object creates a greater biological response10:33
Toxicokinetics12:20
Toxicodinamic14:31
Routes of exposure, translocation to organs and potential health effects of NPs15:36
Proposed mechanisms of NP - induced cytotoxicity.17:00
Proposed mechanisms of NP - induced cytotoxicity.18:41
Titanium dioxide (TiO2)18:50
In vitro studiesTiO220:41
Our studies21:22
Nano TiO2 : 25 nm anatase vs. 10x40 nm rutile22:04
TiO2NP genotoxicity is oxidative stress mediated25:55
Effect of TiO2 NPs on the expression of oxidative stress responsive genes27:33
Pulmonary toxicity of TiO228:23
TiO2 classified as carcinogen29:41
Oral exposureTiO233:11
Dermal exposure to TiO235:45
How nano - TiO2behaves in the presence of UV?38:00
After UV pre - irradiation nanosized and submicron sized anatase TiO2become cytotoxic38:57
After UV pre-irradiation nanosized and submicron sized anatase TiO2 induce more oxidative DNA damage39:34
Implications of these findings40:06
What we know41:07
What we don’t know41:46
Nanoparticle Risk42:39
Risk/benefit43:08
Take home message44:06
“Guilty” or “Not Guilty”46:17
Acknowledgments46:32