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Inferring gene regulatory networks using ensembles of feature selection techniques
Published on Oct 23, 20123264 Views
**Motivation:** One of the long-standing open challenges in computational systems biology is the inference of gene regulatory networks from expression data. Recently, two community-wide efforts have
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Inferring Gene Regulatory Networks using Ensembles of Feature Selection Techniques00:00
Presentation flow00:23
Biological problem - 100:54
What is a gene regulatory network?00:56
Why do we need a gene regulatory network?01:27
Why don’t we have this knowledge?02:22
Complicate02:30
Biological problem - 202:36
Inference problem03:08
Machine learning problem03:42
DREAM5 network inference challenge results03:43
GENIE304:42
Question05:26
Feature importance06:00
Results06:56
DREAM4 dataset06:58
Ensemble settings08:08
Ensemble results08:23
Merging results08:45
Open issues09:43
Potential for improving predictions by merging - 109:48
Potential for improving predictions by merging - 210:32
Current work- open issues11:17
Thank you11:55