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Context-specific transcriptional regulatory network inference from global gene expression maps using double two-way t-tests
Published on Oct 23, 20122783 Views
**Motivation:** Transcriptional regulatory network inference methods have been studied for years. Most of them relie on complex mathematical and algorithmic concepts, making them hard to adapt, re-
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Context-specific transcriptional regulatory network inference from global gene expression maps using double two-way t-tests00:00
Outline - 100:18
Outline - 200:44
Regulation of biological processes in cells00:48
Regulation of nitrogen utilization in yeast01:32
Outline - 303:26
Heatmap03:30
Typical algorithms04:55
Output and evaluation05:12
Benchmark dataset06:14
Outline - 407:15
The differential expression of a gene g08:12
DAL209:11
Outline - 509:45
The interaction score10:07
TFs and their targets10:53
Outline - 611:29
Network inference methods11:38
Recall-precision curves - 112:04
Recall-precision curves - 212:48
Area under the recall-precision curve13:54
Multi-dimensional scaling plot14:07
Distribution of Pearson correlations15:05
Outline - 715:36
Human dataset15:41
Scatter plot of expression levels16:45
Summary17:50