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Truly individualized systems medicine: a hands-on tutorial where participants will resolve paradoxes by using virtual twin/digital-me
Published on Jul 21, 20141556 Views
Misaligned signal transduction, due to oncogenic or other mutations can contribute to disease. By using a preexisting mirror image model of the MAP kinase pathway, the participants will show that ca
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Truly individualized systems medicine: a hands-on tutorial where participants will resolve paradoxes by using virtual twin/digital-me00:00
By way of introduction - 103:07
Systems Biology and Systems Medicine06:14
By way of introduction - 206:48
Life sciences did not yet pay off for medicine because their paradigm entailed12:27
Systems Biology has shown that reality is17:11
Systems Biology has shown that reality is19:44
How do we figure out whether an enzyme is fully rate-limiting for a pathway flux? - 120:53
How do we figure out whether an enzyme is fully rate-limiting for a pathway flux? - 221:15
How does function depend on gene dosage?21:45
The Flux Control Coefficient C - 123:43
The Flux Control Coefficient C - 226:46
The Flux Control Coefficient C - 327:02
The Flux Control Coefficient C - 427:47
Now we have a way to test whether pathways have a single rate limiting step27:48
Experimental: mitochondrial respiration28:31
OK, if it is networks …30:26
We will now deal with the MAPkinase cascade31:02
Precision models have been made for this pathway31:06
Strategy - 131:27
Strategy - 233:40
The simplest version for now - 134:01
Good news for you36:03
The simplest version for now - 237:04
Our aim is to show how these models can be used to 37:17
Paradox 137:19
Paradox 238:22
Paradox 338:59
Paradox 439:26
Well, please sort this out yourselves39:28
Getting the silicon cell environment up and running - 139:41
Getting the silicon cell environment up and running - 240:17
1b. If you do notsee the three windows40:39
2a. The standard state of the model pathway47:03
3c. The effect of kinase activities on x3p (ERK-P)51:31
3d. The effect of kinase activities on x3p (ERK-P)51:32
Untitled51:33
2b. The standard state of the model pathway54:30
3a. The effect of kinase activities on x3p (ERK-P)56:22
3b. The effect of kinase activities on x3p (ERK-P)56:29
Inhibitthe first and the last kinase by 20%56:30
Results57:27
Paradox 157:28
Paradox 259:54
Paradox 301:00:13
Paradox 401:00:34
6c. Calculated effect of the same drug on two different individuals01:00:44