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Systems Pharmacology: An Industry Perspective
Published on Jul 21, 20143803 Views
Systems pharmacology is becoming a key tool for biotherapeutics drug discovery and development. Systems pharmacology utilizes mathematical models that describe the pharmacokinetics and pharmacodynam
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Chapter list
SYSTEMS PHARMACOLOGY: An Industry Perspective00:00
Current landscape00:35
Novel therapeutic strategies: What will bring us from conceptual ideas to solutions to land our compounds on target?01:36
Current challenges in Drug Discovery and Drug Development02:38
Systems Pharmacology for Drug Development05:06
Systems Pharmacology addresses key scientific, competitive, organizational challenges10:03
Typical structure of a Systems Pharmacology model11:19
Enabling Systems Pharmacology: Integrated computational tools13:06
Design of Monoclonal Antibodies for the Treatment of Dengue14:28
Dengue Virus - antibody model16:04
kon Has Profound Impact on Viremia Suppression16:56
Data from Palivizumab, an anti-Respiratory Syncytial Virus antibody, support key role of kon18:40
Vision for Systems Pharmacology20:14
Challenges executing systems pharmacology vision22:15
Two Examples: Diabetes and Cardiac Toxicity23:47
Thank you!25:09