en
0.25
0.5
0.75
1.25
1.5
1.75
2
Circadian control of xenobiotic carcinogenesis and cancer pharmacology
Published on 2014-07-212473 Views
Xenobiotic metabolism and detoxification, as well as cell cycle events, DNA repair, apoptosis and angiogenesis are rhythmically controlled by the Circadian Timing System (CTS), a hierarchical and co
Related categories
Presentation
Circadian Control of Xenobiotic Carcinogenesis and AnticancerDrug Pharmacology00:00
Carcinogenicity of shift-work,painting, and fire-fighting00:00
The ten hallmarks of cancer00:30
The Circadian Timing System02:02
Circadian Timing System ↔ Cancer Progression03:22
CTS disruption on liver cancerogenesis?05:44
The DEN experimental cancer model08:23
Elisabeth Filipski09:58
Number of tumor nodules / liver10:41
Cancer Initiation13:43
Host circadian disruption speeds up cancer15:45
In vitro cancer chronopharmacology16:15
Circadian synchronisation16:36
Genetic clock in human CaCo-2* cell populations17:56
A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery18:51
Irinotecan chronotherapeutic model20:33
Clock-controlled irinotecan bioactivation and detoxification Human CaCo-2 cells at confluence21:11
Clock-controlled irinotecan bioactivation and cytotoxicity (apoptosis)22:21
Clock- Chronopharmacology at cell population level24:14
Sex and genetic differencesin irinotecan chronotolerance in mice : 3 classes24:17
8 h-range for optimal irinotecan timing (tolerability) according to sex & genotype in mice24:35
Which of 27 liver or colon circadian gene transcription patterns predictfor optimal timing if any? 25:55
Conclusions26:55
Thank you28:02