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Circadian control of xenobiotic carcinogenesis and cancer pharmacology
Published on Jul 21, 20142467 Views
Xenobiotic metabolism and detoxification, as well as cell cycle events, DNA repair, apoptosis and angiogenesis are rhythmically controlled by the Circadian Timing System (CTS), a hierarchical and co
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Chapter list
Circadian Control of Xenobiotic Carcinogenesis and AnticancerDrug Pharmacology00:00
Carcinogenicity of shift-work,painting, and fire-fighting00:00
The ten hallmarks of cancer00:30
The Circadian Timing System02:02
Circadian Timing System ↔ Cancer Progression03:22
CTS disruption on liver cancerogenesis?05:44
The DEN experimental cancer model08:23
Elisabeth Filipski09:58
Number of tumor nodules / liver10:41
Cancer Initiation11:54
Cancer Initiation13:43
The ten hallmarks of cancer15:01
Host circadian disruption speeds up cancer15:45
In vitro cancer chronopharmacology16:15
Circadian synchronisation16:36
Genetic clock in human CaCo-2* cell populations17:56
A Combined Experimental and Mathematical Approach for Molecular-based Optimization of Irinotecan Circadian Delivery18:51
Irinotecan chronotherapeutic model20:33
Clock-controlled irinotecan bioactivation and detoxification Human CaCo-2 cells at confluence21:11
Clock-controlled irinotecan bioactivation and cytotoxicity (apoptosis)22:21
Clock-controlled irinotecan bioactivation and cytotoxicity (apoptosis)23:38
Clock- Chronopharmacology at cell population level24:14
Sex and genetic differencesin irinotecan chronotolerance in mice : 3 classes24:17
8 h-range for optimal irinotecan timing (tolerability) according to sex & genotype in mice24:35
Which of 27 liver or colon circadian gene transcription patterns predictfor optimal timing if any? 25:55
Conclusions26:55
Thank you28:02