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Circadian gene expression patterns on the periphery depend on the genotype
Published on Jul 21, 20141553 Views
Questions\\ Biological clock is an important component in body homeostasis. However, it is not clear how the genetic background of each individual influences circadian expression and regulation. We
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Circadian gene expression patterns on the periphery depend on genotype00:00
The circadian clock and mouse strains00:29
Circadian gene expression in mouse strains 129SvPas andC57BL/601:51
Major core clock and metabolic output gene expression differences in adrenals02:33
Differences in peak expression (phase) are most prominent for metabolic genes03:27
Could differences in peak expression be explained by genomic variation of 129 and C57BL/604:09
C57BL6 and 129 strains Differ in over 20.000 snvs and over 150 structural variants05:16
Several SNV variants reside in clock06:12
DNA variations in genes that showed differential circadian expression in C57BL/6 and 129 mice06:45
What could explain the different circadian patterns observed in mouse strains?07:30
Conclusions08:30
Acknowledgments10:11
Thank you!10:33